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A Summary of Recent Updates on the Genetic Determinants of Depression -- Epigenetics of Major Depressive Disorder -- Brain Structural Abnormalities of Major Depressive Disorder -- Cognitive Deficits in Major Depression: From Mechanisms to Management -- Neuroendocrine Alterations in Major Depressive Disorder -- Inflammatory Abnormalities in Major Depressive Disorder -- Psychiatric Comorbidity in Major Depressive Disorder -- Pharmacological Treatment of Major Depressive Disorder -- Neurocircuitry-Based Treatments for Major Depressive Disorder -- Pharmacological and Non-pharmacological Treatment Effects on Functional Outcomes in Major Depressive Disorder -- Internet-Based/Technology-Based Interventions in Major Depressive Disorder -- Dysregulation of the Glutamatergic stem in Major Depressive Disorder